The application "Music" can't be opened. (macOS 27.2)

The Music app fails to open because your user-specific configuration, cache, or home folder permissions in your main account are damaged or conflicting after the update.

Because the app works in another user account and fails even in Safe Mode, the core system application is fine, and the problem is isolated to your user profile files.

Clear the Music App Cache

Corrupted cache files often block native media apps from launching.

• Open Finder.
• Press Command + Shift + G to open the "Go to Folder" search bar and paste the following then press return:

~/Library/Caches/

• Look for folders related to Music or iTunes (such as com.apple.Music or com.apple.iTunes), and move them to the Trash.
• Restart your Mac and try opening Music again (macOS will recreate the caches as needed)

Remove Corrupt Music Preferences

A bad preference plist file can crash the application immediately on launch.

• Open Finder.
• Press Command + Shift + G to open the "Go to Folder" search bar and paste the following then press return:

~/Library/Preferences/

• Find files named com.apple.Music.plist or com.apple.itunes.plist.
• Move them to the Trash (macOS will automatically generate fresh, default preference files when you relaunch Music).

Check Home Folder Permissions

If your user account has broken ownership or read/write permissions on its internal support directories, built-in apps will refuse to start.

• Open Finder and go to your main User home directory (with the House icon).
• Right-click the folder and select Get Info.
• Expand the Sharing & Permissions section at the bottom.
• Click the padlock icon and enter your Mac password to unlock it.
• Ensure your primary user account is listed with Read & Write privileges.
• Click the action button (three dots/gear icon) and select Apply to enclosed items, then confirm.

More info from Apple: Change permissions for files, folders, or disks on Mac - Apple Support

To drill down further and avoid a game of 20 questions, please download EtreCheck directly from the developer.

EtreCheck is not a “silver bullet,” but it is a useful diagnostic tool for examining the hardware and software configuration of your Mac. It does not make changes to your computer.

The application is available in both free and paid versions, with additional features in the paid version.

The report is designed to avoid revealing personal information. However, please review it before posting and redact any sensitive information if necessary.

A few important observations about your issue:

• Since Music opens successfully in another user account on the same Mac, this suggests the problem is specific to your user account rather than a system-wide issue.

• Since the problem persists in Safe Mode, a third-party startup item or extension is less likely to be responsible. Safe Mode limits certain software loaded at startup, but it does not rule out corrupted user-specific preferences, caches, permissions, or other account-level configuration issues.

• Because the problem began after updating to macOS 27.2, the report may help identify software or configuration issues that could be contributing to the problem.

Please post the full EtreCheck report so we can examine the configuration and narrow down the possible cause before attempting further troubleshooting.

Once the scan is complete, select Share Report >> Copy, then paste the report into your reply using the Additional Text icon.

Step 1 — Test Music in Safe Mode

Your EtreCheck report shows repeated crashes in several macOS processes. Safe Mode is a good first test to see whether background software is contributing.

On your M1 Mac mini:

1. Choose Apple menu >> Shut Down and wait for the Mac to turn off.
2. Press and hold the power button until Loading startup options appears.
3. Select your startup disk, hold Shift, then click Continue in Safe Mode.
4. Sign in and try opening Music.

• Music opens: A background component or software interaction may be responsible.
• Music still fails: Continue to Step 2.

See Apple's Safe Mode startup guide.

Restart normally when finished.

Step 2 — Test with a Temporary Music Library

If Safe Mode doesn't help, check whether your existing library is involved without modifying it.

1. Quit Music.
2. Hold Option while launching Music.
3. In the library selection window, choose Create Library.
4. Name the temporary library and save it somewhere convenient.

• Music opens: Your original library, database, or storage location may be involved.
• Music still fails: The cause is more likely elsewhere, although this test isn't conclusive.

Your original library remains untouched. To return to it, quit Music and hold Option while reopening the app, then select your original library.

Step 3 — Examine the Music Crash Report

If Music still won't launch, check for a report that may identify the failure.

1. In Finder, choose Go > Go to Folder.
2. Enter ~/Library/Logs/DiagnosticReports/
3. Find the newest file beginning with Music and ending in .ips.
4. Open it and share its contents.

If no Music report exists, also check /Library/Logs/DiagnosticReports/.

The report may reveal whether Music is crashing during startup or encountering another launch failure.

Before Proceeding

Please confirm:

1. What happens when you launch Music: nothing, a bouncing Dock icon, an immediate crash, an error message, or a hang?
2. Is your main Music library on the internal SSD, an external drive, or primarily in Apple Music/iCloud?
3. Does Music open in Safe Mode?

Start with Step 1. Avoid deleting your library, removing system extensions, or reinstalling macOS until the results point to a more specific cause.

Here's the report:

Thank for your for the Etrecheck Report 

Before we start to analyze it, doing a quick review and notice several External Drives in this configuration 

Per chance, being as the Internal Drive of the M1 Mac Mini is the 256 GB Capacity Size

Are you running your Music Library from one of those drives ?

That may help to put things in context