Safari doesn't register clicks at the bottom (middle) of the window.
I've had this issue for some time, since macOS 14 Sonoma. In Safari, if there is a link at the bottom middle of the screen, it won't register that I've clicked there. If I resize the window, making it smaller, or if I scroll the page so the link is higher, then it works. This has been driving me insane for years now.
POSSIBLE SOLUTION: (from Reddit through apple.stackexchange.com) If you have enabled Developer Mode in Safari, go to the Debug menu and unselect Show Resource Usage Overlay.
This has totally resolved my issue. Hopefully, this works for others.